{"id":123,"date":"2023-03-27T09:32:16","date_gmt":"2023-03-27T09:32:16","guid":{"rendered":"https:\/\/therapia.ge\/?p=123"},"modified":"2023-03-27T10:12:31","modified_gmt":"2023-03-27T10:12:31","slug":"cyp2c19-%e1%83%98%e1%83%a1%e1%83%93%e1%83%90-il1b-%e1%83%98%e1%83%a1%e1%83%92%e1%83%94%e1%83%9c%e1%83%94%e1%83%a2%e1%83%98%e1%83%99%e1%83%a3%e1%83%a0-%e1%83%9e%e1%83%9d%e1%83%9a%e1%83%98%e1%83%9b","status":"publish","type":"post","link":"https:\/\/therapia.ge\/cyp2c19-%e1%83%98%e1%83%a1%e1%83%93%e1%83%90-il1b-%e1%83%98%e1%83%a1%e1%83%92%e1%83%94%e1%83%9c%e1%83%94%e1%83%a2%e1%83%98%e1%83%99%e1%83%a3%e1%83%a0-%e1%83%9e%e1%83%9d%e1%83%9a%e1%83%98%e1%83%9b\/","title":{"rendered":"<strong>CYP2C19-\u10d8\u10e1\u10d3\u10d0 IL1B-\u10d8\u10e1\u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0 \u10de\u10dd\u10da\u10d8\u10db\u10dd\u10e0\u10e4\u10d8\u10d6\u10db\u10d4\u10d1\u10e1\u10d0\u10e0 \u10d0\u10e5\u10d5\u10e1 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0 \u10d4\u10d6\u10dd\u10db\u10d4\u10de\u10e0\u10d0\u10d6\u10dd\u10da\u10d8\u10d7\u10db\u10e1\u10e3\u10d1\u10e3\u10e5\u10d8 \u10d4\u10e0\u10dd\u10d6\u10d8\u10e3\u10da\u10d8 \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10d8\u10e2\u10d8\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10d6\u10d4<\/strong>"},"content":{"rendered":"\n<div class=\"wp-block-file\"><a id=\"wp-block-file--media-a9025e13-9dc9-4b1f-916d-57ebcd6f7c96\" href=\"https:\/\/therapia.ge\/wp-content\/uploads\/2023\/03\/4.-genetic-polymorphisms-of-cyp2c19-and-il1bhave-no-in\ufb02uence-on-esomepra....docx\">4.-genetic-polymorphisms-of-cyp2c19-and-il1bhave-no-in\ufb02uence-on-esomepra&#8230;<\/a><a href=\"https:\/\/therapia.ge\/wp-content\/uploads\/2023\/03\/4.-genetic-polymorphisms-of-cyp2c19-and-il1bhave-no-in\ufb02uence-on-esomepra....docx\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-a9025e13-9dc9-4b1f-916d-57ebcd6f7c96\">\u10d2\u10d0\u10d3\u10db\u10dd\u10ec\u10d4\u10e0\u10d0<\/a><\/div>\n\n\n\n<p><strong>\u10d5\u10d4\u10dc-\u10f0\u10e3\u10dc\u10d2 \u10f0\u10e1\u10e3,<\/strong><\/p>\n\n\n\n<p>\u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10dc\u10e2\u10d4\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e7\u10dd\u10e4\u10d8\u10da\u10d4\u10d1\u10d0, \u10e8\u10d8\u10dc\u10d0\u10d2\u10d0\u10dc\u10d8 \u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8\u10e1 \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10e1\u10d0\u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10dd \u10f0\u10dd\u10e1\u10de\u10d8\u10e2\u10d0\u10da\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8, \u10e2\u10d0\u10d8\u10d5\u10d0\u10dc\u10d8<\/p>\n\n\n\n<p><strong>\u10e4\u10e3-\u10e9\u10d4\u10dc \u10d9\u10e3\u10dd,<\/strong><\/p>\n\n\n\n<p>\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1 \u10e1\u10d9\u10dd\u10da\u10d0, \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10d9\u10dd\u10da\u10d4\u10ef\u10d8, \u10d4-\u10d3\u10d0\u10e1 \u10f0\u10dd\u10e1\u10de\u10d8\u10e2\u10d0\u10da\u10d8, \u10d8-\u10e8\u10dd\u10e3\u10e1 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8, \u10e2\u10d0\u10d8\u10d5\u10d0\u10dc\u10d8<\/p>\n\n\n\n<p><strong>\u10f0\u10e3\u10d0\u10dc\u10d2-\u10db\u10d8\u10dc\u10d2 \u10f0\u10e3,<\/strong><\/p>\n\n\n\n<p>\u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10dc\u10e2\u10d4\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e7\u10dd\u10e4\u10d8\u10da\u10d4\u10d1\u10d0, \u10e8\u10d8\u10dc\u10d0\u10d2\u10d0\u10dc\u10d8 \u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d4\u10e0\u10d7\u10dd \u10f0\u10dd\u10e1\u10de\u10d8\u10e2\u10d0\u10da\u10d8 \u10d3\u10d0 \u10d8\u10d0\u10dc\u10d2-\u10db\u10d8\u10dc\u10d2\u10d8\u10e1 \u10d4\u10e0\u10dd\u10d5\u10dc\u10e3\u10da\u10d8 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8, \u10e2\u10d0\u10d8\u10d5\u10d0\u10dc\u10d8<\/p>\n\n\n\n<p><strong>\u10de\u10d8\u10dc\u10d2-\u10d8 \u10f0\u10e1\u10e3<\/strong>,<\/p>\n\n\n\n<p>\u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10dc\u10e2\u10d4\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e7\u10dd\u10e4\u10d8\u10da\u10d4\u10d1\u10d0, \u10e8\u10d8\u10dc\u10d0\u10d2\u10d0\u10dc\u10d8 \u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d4\u10e0\u10d7\u10dd \u10f0\u10dd\u10e1\u10de\u10d8\u10e2\u10d0\u10da\u10d8 \u10d3\u10d0 \u10d8\u10d0\u10dc\u10d2-\u10db\u10d8\u10dc\u10d2\u10d8\u10e1 \u10d4\u10e0\u10dd\u10d5\u10dc\u10e3\u10da\u10d8 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8, \u10e2\u10d0\u10d8\u10d5\u10d0\u10dc\u10d8<\/p>\n\n\n\n<p><strong>\u10d3\u10d4\u10dc\u10d2-\u10e9\u10d8\u10d0\u10dc\u10d2 \u10d5\u10e3,<\/strong><\/p>\n\n\n\n<p>\u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d9\u10d8\u10d1\u10dd\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10d7\u10d8 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8\u10e1 \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8, \u10e2\u10d0\u10d8\u10d5\u10d0\u10dc\u10d8<\/p>\n\n\n\n<p><strong>\u10e9\u10d0\u10dd-\u10f0\u10e3\u10dc\u10d2 \u10d9\u10e3\u10dd,<\/strong><\/p>\n\n\n\n<p>\u10e6\u10d4\u10e0\u10dd\u10d5\u10d0\u10dc\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10d7\u10d8 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8\u10e1 \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8, \u10e2\u10d0\u10d8\u10d5\u10d0\u10dc\u10d8<\/p>\n\n\n\n<p>Wen-Hung Hsu, Fu-Chen Kuo, Huang-Ming Hu, Ping-I Hsu, Deng-Chyang Wu, Chao-Hung Kuo<\/p>\n\n\n\n<p><strong>\u10d0\u10d1\u10e1\u10e2\u10e0\u10d0\u10e5\u10e2\u10d8<\/strong><\/p>\n\n\n\n<p>\u10d8\u10dc\u10e2\u10d4\u10e0\u10da\u10d4\u10d8\u10d9\u10d8\u10dc\u10d8 (IL)-1b \u10ec\u10d0\u10e0\u10db\u10dd\u10d0\u10d3\u10d2\u10d4\u10dc\u10e1 \u10d9\u10e3\u10ed\u10d8\u10e1 \u10db\u10df\u10d0\u10d5\u10d0\u10e1 \u10e1\u10d4\u10d9\u10e0\u10d4\u10ea\u10d8\u10d8\u10e1 \u10eb\u10da\u10d8\u10d4\u10e0 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10e1 \u10d3\u10d0 \u10db\u10d8\u10e1\u10d8 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10de\u10dd\u10da\u10d8\u10db\u10dd\u10e0\u10e4\u10d8\u10d6\u10db\u10d8 \u10e3\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10d8\u10e2\u10d8\u10e1 \u10e1\u10d8\u10db\u10eb\u10d8\u10db\u10d4\u10e1. \u10de\u10e0\u10dd\u10e2\u10dd\u10dc\u10d8\u10e1 \u10e2\u10e3\u10db\u10d1\u10dd\u10e1 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d8 (PPI), \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10db\u10d4\u10e2\u10d0\u10d1\u10dd\u10da\u10d8\u10d6\u10d3\u10d4\u10d1\u10d0 P450 2C19-\u10d8\u10e1 (CYP2C19) \u10db\u10d8\u10d4\u10e0, \u10ec\u10d0\u10e0\u10db\u10dd\u10d0\u10d3\u10d2\u10d4\u10dc\u10e1 \u10ec\u10d0\u10db\u10e7\u10d5\u10d0\u10dc \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10e1 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10d8\u10e2\u10d8\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10e8\u10d8. CYP2C19 \u10d2\u10d4\u10dc\u10dd\u10e2\u10d8\u10de\u10db\u10d0 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0 \u10db\u10dd\u10d0\u10ee\u10d3\u10d8\u10dc\u10dd\u10e1 PPI-\u10d8\u10e1 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da \u10d4\u10e4\u10d4\u10e5\u10e2\u10d6\u10d4 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10d8\u10e2\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1. 2009 \u10ec\u10da\u10d8\u10e1 \u10dc\u10dd\u10d4\u10db\u10d1\u10e0\u10d8\u10d3\u10d0\u10dc 2012 \u10ec\u10da\u10d8\u10e1 \u10d8\u10d5\u10dc\u10d8\u10e1\u10d0\u10db\u10d3\u10d4, \u10d0\u10db \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10e8\u10d8 \u10db\u10dd\u10ee\u10d3\u10d0 184 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d8\u10e1 \u10e9\u10d0\u10e0\u10d7\u10d5\u10d0 \u10d4\u10dc\u10d3\u10dd\u10e1\u10d9\u10dd\u10de\u10d8\u10e3\u10e0\u10d8 \u10e8\u10d4\u10db\u10dd\u10ec\u10db\u10d4\u10d1\u10d8\u10e1, \u10d4\u10d6\u10dd\u10db\u10d4\u10de\u10e0\u10d0\u10d6\u10dd\u10da\u10d8\u10d7 8-\u10d9\u10d5\u10d8\u10e0\u10d8\u10d0\u10dc\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1, \u10d3\u10d0 \u10d9\u10d8\u10d7\u10ee\u10d5\u10d0\u10e0\u10d8\u10d7 20-\u10d9\u10d5\u10d8\u10e0\u10d8\u10d0\u10dc\u10d8 \u10d3\u10d0\u10d9\u10d5\u10d8\u10e0\u10d5\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10e4\u10e3\u10eb\u10d5\u10d4\u10da\u10d6\u10d4. \u10d0\u10db \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e1 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10e9\u10d0\u10e3\u10e2\u10d0\u10e0\u10d3\u10d0\u10d7 \u10d4\u10dc\u10d3\u10dd\u10e1\u10d9\u10dd\u10de\u10d8\u10e3\u10e0\u10d8 \u10e8\u10d4\u10db\u10dd\u10ec\u10db\u10d4\u10d1\u10d0 20 \u10d9\u10d5\u10d8\u10e0\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2. \u10db\u10dd\u10ee\u10d3\u10d0 \u10e1\u10d8\u10e1\u10ee\u10da\u10d8\u10e1 \u10d0\u10e6\u10d4\u10d1\u10d0 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10de\u10dd\u10da\u10d8\u10db\u10dd\u10e0\u10e4\u10d8\u10d6\u10db\u10d8\u10e1 \u10d0\u10dc\u10d0\u10da\u10d8\u10d6\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10de\u10dd\u10da\u10d8\u10db\u10d4\u10e0\u10d0\u10d6\u10e3\u10da \u10ef\u10d0\u10ed\u10d5\u10e3\u10e0\u10d8 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d8\u10e1 \u10db\u10d4\u10e8\u10d5\u10d4\u10dd\u10d1\u10d8\u10d7. \u10d4\u10d6\u10dd\u10db\u10d4\u10de\u10e0\u10d0\u10d6\u10dd\u10da\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 8 \u10d9\u10d5\u10d8\u10e0\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2, 184-\u10d5\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10db\u10d0 \u10db\u10d8\u10d0\u10e6\u10ec\u10d8\u10d0 \u10e1\u10e0\u10e3\u10da\u10e7\u10dd\u10e4\u10d8\u10da \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10e3\u10e0 \u10e8\u10d5\u10d4\u10d1\u10d0\u10e1. \u10d7\u10e3\u10db\u10ea\u10d0\u10e6\u10d0, \u10e8\u10d4\u10db\u10d3\u10d4\u10d2\u10d8 12 \u10d9\u10d5\u10d8\u10e0\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8, 58.70% (108\/184) \u10e3\u10e9\u10d8\u10dd\u10d3\u10d0 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d4\u10ea\u10d8\u10d3\u10d8\u10d5\u10e1, 45.65% (84\/184) \u10f0\u10e5\u10dd\u10dc\u10d3\u10d0 \u10db\u10d3\u10d2\u10e0\u10d0\u10d3\u10d8 \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10e3\u10e0\u10d8 \u10d4\u10e0\u10dd\u10d6\u10d8\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d3\u10d0 \u10d4\u10dc\u10d3\u10dd\u10e1\u10d9\u10dd\u10de\u10d8\u10d8\u10d7, \u10d3\u10d0 \u10ef\u10d0\u10db\u10e8\u10d8, \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 76.09% (140\/184) \u10f0\u10e5\u10dd\u10dc\u10d3\u10d0 \u10ec\u10d0\u10e0\u10e3\u10db\u10d0\u10e2\u10d4\u10d1\u10d4\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10db\u10d4-20 \u10d9\u10d5\u10d8\u10e0\u10d8\u10e1 \u10d1\u10dd\u10da\u10dd\u10e1\u10d7\u10d5\u10d8\u10e1. \u10d0\u10e0 \u10e7\u10dd\u10e4\u10d8\u10da\u10d0 CYP2C19 \u10d3\u10d0 IL1B-\u10d8\u10e1 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10de\u10dd\u10da\u10d8\u10db\u10dd\u10e0\u10e4\u10d8\u10d6\u10db\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10ec\u10d0\u10e0\u10e3\u10db\u10d0\u10e2\u10d4\u10d1\u10da\u10dd\u10d1\u10d0\u10d6\u10d4 (p Z 0.896). \u10d0\u10db\u10d2\u10d5\u10d0\u10e0\u10d0\u10d3, PPI \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d2\u10d0\u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10ea\u10ee\u10dd\u10d5\u10e0\u10d4\u10d1\u10d8\u10e1 \u10ec\u10d4\u10e1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d2\u10dd\u10db\u10d8 \u10db\u10dd\u10d3\u10d8\u10e4\u10d8\u10d9\u10d0\u10ea\u10d8\u10d0 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10e0\u10d0\u10dc\u10e2\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd\u10e1 \u10db\u10e1\u10e3\u10d1\u10e3\u10e5\u10d8 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10e3\u10e0\u10d8 \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10d8\u10e2\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1. \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d8 IL-1b-\u10e1\u10d0 \u10d3\u10d0 CYP2C19-\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10db\u10e1\u10e3\u10d1\u10e3\u10e5\u10d8 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10d8\u10e2\u10d8\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e8\u10d8.<\/p>\n\n\n\n<p>\u10e1\u10d0\u10d0\u10d5\u10e2\u10dd\u10e0\u10dd \u10e3\u10e4\u10da\u10d4\u10d1\u10d4\u10d1\u10d8 \u00aa 2015, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8 \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8. \u10d2\u10d0\u10db\u10dd\u10e5\u10d5\u10d4\u10e7\u10dc\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10e8\u10de\u10e1 Elsevier \u10e2\u10d0\u10d8\u10d5\u10d0\u10dc\u10d8\u10e1 \u10db\u10d8\u10d4\u10e0. \u10e7\u10d5\u10d4\u10da\u10d0 \u10e3\u10e4\u10da\u10d4\u10d1\u10d0 \u10d3\u10d0\u10ea\u10e3\u10da\u10d8\u10d0.<\/p>\n\n\n\n<p><strong>\u10e8\u10d4\u10e1\u10d0\u10d5\u10d0\u10da\u10d8<\/strong><\/p>\n\n\n\n<p>\u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10e3\u10e0\u10d8 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0 (GERD), \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d2\u10d0\u10dc\u10d8\u10e1\u10d0\u10d6\u10e6\u10d5\u10e0\u10d4\u10d1\u10d0, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10d9\u10e3\u10ed\u10d8\u10e1 \u10e8\u10d8\u10d2\u10d7\u10d0\u10d5\u10e1\u10d8\u10e1 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10d8, \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10e8\u10d4\u10db\u10d0\u10ec\u10e3\u10ee\u10d4\u10d1\u10d4\u10da \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10e1\u10d0 \u10d3\u10d0 \u10d2\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10e1, \u10d3\u10d0 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10e3\u10da\u10d8 \u10e5\u10e0\u10dd\u10dc\u10d8\u10d9\u10e3\u10da \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10d0\u10d3\u10d2\u10d4\u10dc\u10e1 \u10d1\u10d4\u10d5\u10e0\u10d8 \u10e5\u10d5\u10d4\u10e7\u10dc\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 [1,2]. \u10d0\u10d6\u10d8\u10d0\u10e8\u10d8, \u10db\u10d8\u10e9\u10dc\u10d4\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd, \u10e0\u10dd\u10db \u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10e3\u10e0\u10d8 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10d4\u10d5\u10d0\u10da\u10d4\u10dc\u10e2\u10dd\u10d1\u10d0 &lt; 5%-\u10d8\u10d0, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10d1\u10dd\u10da\u10dd\u10d3\u10e0\u10dd\u10d8\u10dc\u10d3\u10d4\u10da \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8, \u10d8\u10d2\u10d8 15%-\u10db\u10d3\u10d4 \u10d2\u10d0\u10d8\u10d6\u10d0\u10e0\u10d3\u10d0 \u10d3\u10d0 \u10db\u10d8\u10e9\u10dc\u10d4\u10e3\u10da\u10d8\u10d0, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10de\u10e0\u10dd\u10d1\u10da\u10d4\u10db\u10d0 \u10e1\u10d0\u10db\u10dd\u10db\u10d0\u10d5\u10da\u10dd\u10d3 [3-5]. \u10ec\u10d8\u10dc\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8, \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10d8\u10e2\u10d8 \u10db\u10d8\u10e9\u10dc\u10d4\u10e3\u10da \u10d8\u10e7\u10dd \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10db\u10e3\u10da\u10e2\u10d8\u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d6\u10d4\u10ea \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0\u10e1 \u10d0\u10ee\u10d3\u10d4\u10dc\u10e1 \u10d2\u10d0\u10e0\u10d4\u10db\u10dd \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d4\u10d1\u10d8\u10ea\u10d0\u10d0 \u10d9\u10d5\u10d4\u10d1\u10d8\u10d7\u10d8 \u10e5\u10ea\u10d4\u10d5\u10d0, \u10dc\u10d0\u10e0\u10d9\u10dd\u10e2\u10d8\u10d9\u10d4\u10d1\u10d8\u10e1 \u10db\u10dd\u10ee\u10db\u10d0\u10e0\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10e4\u10e1\u10d8\u10e5\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 [4]. \u10d1\u10dd\u10da\u10dd \u10d3\u10d4\u10d9\u10d0\u10d3\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8, \u10db\u10dd\u10ee\u10d3\u10d0 \u10d2\u10d4\u10dc\u10e3\u10e0\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e7\u10d5\u10d0\u10d5\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10d0\u10e6\u10db\u10dd\u10e9\u10dc\u10d3\u10d0, \u10e0\u10dd\u10db \u10d8\u10dc\u10e2\u10d4\u10e0\u10da\u10d4\u10d8\u10d9\u10d8\u10dc\u10d8 (IL)-1b \u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10e8\u10d8\u10d0 \u10db\u10df\u10d0\u10d5\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d7\u10d0\u10dc, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d4\u10d1\u10d8\u10ea\u10d0\u10d0 \u10de\u10d4\u10de\u10e2\u10d8\u10e3\u10e0\u10d8 \u10ec\u10e7\u10da\u10e3\u10da\u10d8 \u10d3\u10d0 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10d8\u10e2\u10d8 [6-8]. \u10de\u10e0\u10dd\u10e2\u10dd\u10dc\u10d8\u10e1 \u10e2\u10e3\u10db\u10d1\u10dd\u10e1 \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d8 (PPI) \u10ec\u10d0\u10e0\u10db\u10dd\u10d0\u10d3\u10d2\u10d4\u10dc\u10d3\u10d0 \u10db\u10df\u10d0\u10d5\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e1\u10d0\u10e4\u10e3\u10eb\u10d5\u10d4\u10da\u10e1, \u10de\u10d4\u10de\u10e2\u10d8\u10e3\u10e0\u10d8 \u10ec\u10e7\u10da\u10e3\u10da\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10e3\u10e0\u10d8 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e9\u10d0\u10d7\u10d5\u10da\u10d8\u10d7 [9]. \u10d0\u10db \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8\u10e1 \u10e4\u10d0\u10e0\u10d7\u10dd\u10d3 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10d0 \u10d2\u10d0\u10d0\u10d6\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2, \u10db\u10d8\u10e9\u10dc\u10d4\u10e3\u10da \u10d8\u10e5\u10dc\u10d0, \u10e0\u10dd\u10db \u10db\u10d4\u10e2\u10d0\u10d1\u10dd\u10da\u10e3\u10e0\u10d8 \u10d2\u10d6\u10d0 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0\u10e1 \u10d0\u10ee\u10d3\u10d4\u10dc\u10e1 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da \u10d4\u10e4\u10d4\u10e5\u10e2\u10d6\u10d4. \u10ea\u10d8\u10e2\u10dd\u10e5\u10e0\u10dd\u10db 450-\u10d8\u10e1 \u10e4\u10d4\u10e0\u10db\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8 \u10d0\u10ec\u10d5\u10d3\u10d8\u10d0\u10dc \u10db\u10d7\u10d0\u10d5\u10d0\u10e0 \u10d2\u10d6\u10d0\u10e1 PPI-\u10d8\u10e1 \u10db\u10d4\u10e2\u10d0\u10d1\u10dd\u10da\u10d8\u10d6\u10db\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d3\u10d0 CYP2C19-\u10d8\u10e1 \u10d2\u10d4\u10dc\u10dd\u10e2\u10d8\u10de\u10e1 \u10d0\u10e5\u10d5\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0 PPI-\u10d8\u10e1 \u10e4\u10d0\u10e0\u10db\u10d0\u10d9\u10dd\u10d3\u10d8\u10dc\u10d0\u10db\u10d8\u10d9\u10d0\u10d6\u10d4. CYP2C19-\u10d8\u10e1 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0 \u10de\u10dd\u10da\u10d8\u10db\u10dd\u10e0\u10e4\u10d8\u10d6\u10db\u10e1 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0 \u10d0\u10e5\u10d5\u10e1 Helicobacter pylori-\u10d8\u10e1 PPI-\u10d6\u10d4 \u10d3\u10d0\u10e4\u10e3\u10eb\u10dc\u10d4\u10d1\u10e3\u10da \u10d4\u10e0\u10d0\u10d3\u10d8\u10d9\u10d0\u10ea\u10d8\u10d0\u10d6\u10d4 [10,11]. \u10d6\u10dd\u10d2\u10d8\u10d4\u10e0\u10d7\u10d8 \u10db\u10dd\u10ee\u10e1\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10d2\u10d5\u10d0\u10db\u10ea\u10dc\u10dd\u10d1\u10e1, \u10e0\u10dd\u10db \u10db\u10d0\u10e1 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0 \u10d0\u10e5\u10d5\u10e1 \u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10e3\u10e0\u10d8 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10d6\u10d4 [12,13].<\/p>\n\n\n\n<p>\u10e9\u10d5\u10d4\u10dc\u10d8 \u10db\u10d8\u10d6\u10d0\u10dc\u10d8\u10d0, \u10d2\u10d0\u10dc\u10d5\u10e1\u10d0\u10d6\u10e6\u10d5\u10e0\u10dd\u10d7 IL1B-\u10d8\u10e1 \u10d3\u10d0 CYP2C19-\u10d8\u10e1 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10de\u10dd\u10da\u10d8\u10db\u10dd\u10e0\u10e4\u10d8\u10d6\u10db\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0 \u10e0\u10d4\u10e4\u10da\u10e3\u10e5\u10e1\u10e3\u10e0\u10d8 \u10d4\u10d6\u10dd\u10e4\u10d0\u10d2\u10d8\u10e2\u10d8\u10e1 PPI-\u10d8\u10d7 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10d6\u10d4.<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/therapia.ge\/wp-content\/uploads\/2023\/03\/genetic-polymorphisms-of-cyp2c19-and-il1bhave-no-in\ufb02uence-on-esomeprazol....pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"\u10e9\u10d0\u10d3\u10d2\u10db\u10d0 genetic-polymorphisms-of-cyp2c19-and-il1bhave-no-in\ufb02uence-on-esomeprazol....\"><\/object><a id=\"wp-block-file--media-b5ed5aa2-7f71-47d6-a24f-e4651856ea96\" href=\"https:\/\/therapia.ge\/wp-content\/uploads\/2023\/03\/genetic-polymorphisms-of-cyp2c19-and-il1bhave-no-in\ufb02uence-on-esomeprazol....pdf\">genetic-polymorphisms-of-cyp2c19-and-il1bhave-no-in\ufb02uence-on-esomeprazol&#8230;<\/a><a href=\"https:\/\/therapia.ge\/wp-content\/uploads\/2023\/03\/genetic-polymorphisms-of-cyp2c19-and-il1bhave-no-in\ufb02uence-on-esomeprazol....pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-b5ed5aa2-7f71-47d6-a24f-e4651856ea96\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u10d5\u10d4\u10dc-\u10f0\u10e3\u10dc\u10d2 \u10f0\u10e1\u10e3, \u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10dc\u10e2\u10d4\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e7\u10dd\u10e4\u10d8\u10da\u10d4\u10d1\u10d0, \u10e8\u10d8\u10dc\u10d0\u10d2\u10d0\u10dc\u10d8 \u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8\u10e1 \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10e1\u10d0\u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10dd \u10f0\u10dd\u10e1\u10de\u10d8\u10e2\u10d0\u10da\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8, \u10e2\u10d0\u10d8\u10d5\u10d0\u10dc\u10d8 \u10e4\u10e3-\u10e9\u10d4\u10dc \u10d9\u10e3\u10dd, \u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1 \u10e1\u10d9\u10dd\u10da\u10d0, \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10d9\u10dd\u10da\u10d4\u10ef\u10d8, \u10d4-\u10d3\u10d0\u10e1 \u10f0\u10dd\u10e1\u10de\u10d8\u10e2\u10d0\u10da\u10d8, \u10d8-\u10e8\u10dd\u10e3\u10e1 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8, \u10e2\u10d0\u10d8\u10d5\u10d0\u10dc\u10d8 \u10f0\u10e3\u10d0\u10dc\u10d2-\u10db\u10d8\u10dc\u10d2 \u10f0\u10e3, \u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10dc\u10e2\u10d4\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e7\u10dd\u10e4\u10d8\u10da\u10d4\u10d1\u10d0, \u10e8\u10d8\u10dc\u10d0\u10d2\u10d0\u10dc\u10d8 \u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d4\u10e0\u10d7\u10dd \u10f0\u10dd\u10e1\u10de\u10d8\u10e2\u10d0\u10da\u10d8 \u10d3\u10d0 \u10d8\u10d0\u10dc\u10d2-\u10db\u10d8\u10dc\u10d2\u10d8\u10e1 \u10d4\u10e0\u10dd\u10d5\u10dc\u10e3\u10da\u10d8 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8, \u10e2\u10d0\u10d8\u10d5\u10d0\u10dc\u10d8 \u10de\u10d8\u10dc\u10d2-\u10d8 \u10f0\u10e1\u10e3, \u10d2\u10d0\u10e1\u10e2\u10e0\u10dd\u10d4\u10dc\u10e2\u10d4\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e7\u10dd\u10e4\u10d8\u10da\u10d4\u10d1\u10d0, \u10e8\u10d8\u10dc\u10d0\u10d2\u10d0\u10dc\u10d8 \u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8, \u10d9\u10d0\u10dd\u10f0\u10e1\u10d8\u10e3\u10dc\u10d2\u10d8 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d4\u10e0\u10d7\u10dd \u10f0\u10dd\u10e1\u10de\u10d8\u10e2\u10d0\u10da\u10d8 \u10d3\u10d0 \u10d8\u10d0\u10dc\u10d2-\u10db\u10d8\u10dc\u10d2\u10d8\u10e1 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