{"id":97,"date":"2023-03-27T09:00:55","date_gmt":"2023-03-27T09:00:55","guid":{"rendered":"https:\/\/therapia.ge\/?p=97"},"modified":"2023-03-27T10:09:01","modified_gmt":"2023-03-27T10:09:01","slug":"tavis-tvinisa-da-periferiuli","status":"publish","type":"post","link":"https:\/\/therapia.ge\/tavis-tvinisa-da-periferiuli\/","title":{"rendered":"\u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10d0\u10e2\u10d8\u10de\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 \u10ee\u10d4\u10da\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10d4\u10dc \u10dc\u10d4\u10d8\u10e0\u10dd-\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0\u10e1"},"content":{"rendered":"\n<div class=\"wp-block-file\"><a id=\"wp-block-file--media-6a5a71c2-870d-4edb-aee1-e014fef67251\" href=\"https:\/\/therapia.ge\/wp-content\/uploads\/2023\/03\/Brain-and-Peripheral-Atypical-Inflammatory-Mediators_.docx\">Brain-and-Peripheral-Atypical-Inflammatory-Mediators_<\/a><a href=\"https:\/\/therapia.ge\/wp-content\/uploads\/2023\/03\/Brain-and-Peripheral-Atypical-Inflammatory-Mediators_.docx\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-6a5a71c2-870d-4edb-aee1-e014fef67251\"><strong>\u10d2\u10d0\u10d3\u10db\u10dd\u10ec\u10d4\u10e0\u10d0<\/strong><\/a><\/div>\n\n\n\n<p>\u10d3\u10e3\u10e0\u10d0\u10d8\u10e1\u10d0\u10db\u10d8\u10d0 \u10d9\u10d4\u10db\u10de\u10e3\u10e0\u10d0\u10ef\u10d8,<\/p>\n\n\n\n<p>\u10f0\u10d0\u10e0\u10d8 \u10e1. \u10e2\u10e0\u10e3\u10db\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10ee\u10d4\u10da\u10dd\u10d1\u10d8\u10e1 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d0\u10d5\u10d0\u10d3\u10db\u10e7\u10dd\u10e4\u10dd, \u10d0\u10e8\u10e8-\u10d8\u10e1 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d7\u10d0 \u10e1\u10d0\u10e5\u10db\u10d4\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8, \u10d9\u10dd\u10da\u10e3\u10db\u10d1\u10d8\u10d0, MO, \u10e8\u10d4\u10d4\u10e0\u10d7\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10e2\u10d0\u10e2\u10d4\u10d1\u10d8<\/p>\n\n\n\n<p>\u10e0\u10d0\u10db\u10d0\u10e1\u10d0\u10db\u10d8 \u10e2\u10d0\u10dc\u10d2\u10d0\u10d5\u10d4\u10da\u10d8,<\/p>\n\n\n\n<p>\u10db\u10d8\u10e1\u10e3\u10e0\u10d8\u10e1 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8\u10e1 \u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1&nbsp; \u10d3\u10d0 \u10e2\u10e0\u10d0\u10dc\u10e1\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d8,&nbsp; \u10d9\u10dd\u10da\u10e3\u10db\u10d1\u10d8\u10d0, MO, \u10e8\u10d4\u10d4\u10e0\u10d7\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10e2\u10d0\u10e2\u10d4\u10d1\u10d8<\/p>\n\n\n\n<p>\u10d2\u10dd\u10d5\u10d8\u10dc\u10d3\u10d0\u10e1\u10d0\u10db\u10d8 \u10de.\u10e1\u10d4\u10da\u10d5\u10d0\u10d9\u10e3\u10db\u10d0\u10e0\u10d8,<\/p>\n\n\n\n<p>\u10f0\u10d0\u10e0\u10d8 \u10e1. \u10e2\u10e0\u10e3\u10db\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10ee\u10d4\u10da\u10dd\u10d1\u10d8\u10e1 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d0\u10d5\u10d0\u10d3\u10db\u10e7\u10dd\u10e4\u10dd, \u10d0\u10e8\u10e8-\u10d8\u10e1 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d7\u10d0 \u10e1\u10d0\u10e5\u10db\u10d4\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8, \u10d9\u10dd\u10da\u10e3\u10db\u10d1\u10d8\u10d0, MO, \u10e8\u10d4\u10d4\u10e0\u10d7\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10e2\u10d0\u10e2\u10d4\u10d1\u10d8<\/p>\n\n\n\n<p>\u10e1\u10db\u10d8\u10e2\u10d0 \u10d6\u10d0\u10f0\u10d4\u10e0\u10d8,<\/p>\n\n\n\n<p>\u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8 \u10d3\u10d0 \u10e2\u10e0\u10d0\u10dc\u10e1\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d8, \u10db\u10d8\u10e1\u10e3\u10e0\u10d8\u10e1 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8, \u10d9\u10dd\u10da\u10e3\u10db\u10d1\u10d8\u10d0, MO, \u10e8\u10d4\u10d4\u10e0\u10d7\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10e2\u10d0\u10e2\u10d4\u10d1\u10d8<\/p>\n\n\n\n<p>\u10db\u10dd\u10f0\u10d0\u10db\u10d0\u10d3 \u10d0\u10f0\u10db\u10d4\u10d3\u10d8,<\/p>\n\n\n\n<p>\u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8 \u10d3\u10d0 \u10e2\u10e0\u10d0\u10dc\u10e1\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d8, \u10db\u10d8\u10e1\u10e3\u10e0\u10d8\u10e1 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8, \u10d9\u10dd\u10da\u10e3\u10db\u10d1\u10d8\u10d0, MO, \u10e8\u10d4\u10d4\u10e0\u10d7\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10e2\u10d0\u10e2\u10d4\u10d1\u10d8<\/p>\n\n\n\n<p><a href=\"http:\/\/loop.frontiersin.org\/people\/391552\/overview\">Duraisamy Kempuraj <\/a>, Ramasamy Thangavel , Govindhasamy P. Selvakumar , &nbsp;Smita Zaheer, Mohammad &nbsp;Ahmed<\/p>\n\n\n\n<p><strong>\u10d0\u10d1\u10e1\u10e2\u10e0\u10d0\u10e5\u10e2\u10d8<\/strong><\/p>\n\n\n\n<p>&nbsp;&nbsp; \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d0, \u10de\u10d8\u10e0\u10d5\u10d4\u10da \u10e0\u10d8\u10d2\u10e8\u10d8, \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10d3\u10d0\u10db\u10ea\u10d0\u10d5\u10d8 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8\u10d0. \u10d7\u10e3\u10db\u10ea\u10d0, \u10d2\u10d0\u10d3\u10d0\u10ed\u10d0\u10e0\u10d1\u10d4\u10d1\u10e3\u10da\u10db\u10d0 \u10d3\u10d0 \u10e5\u10e0\u10dd\u10dc\u10d8\u10d9\u10e3\u10da\u10db\u10d0 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10db\u10d0 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d4\u10d1\u10db\u10d0 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10dd\u10e1 \u10db\u10d0\u10d5\u10dc\u10d4 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d4\u10d1\u10d8 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1, \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d0\u10e1\u10d8\u10d2\u10dc\u10d0\u10da\u10dd \u10db\u10dd\u10da\u10d4\u10d9\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10db\u10dd\u10dc\u10d0\u10ec\u10d8\u10da\u10d4\u10dd\u10d1\u10d8\u10d7. \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10d3\u10d0 \u10d0\u10e9\u10e5\u10d0\u10e0\u10d4\u10d1\u10e1 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 (PD), \u10d0\u10da\u10ea\u10f0\u10d4\u10d8\u10db\u10d4\u10e0\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 (AD) \u10d3\u10d0 \u10d2\u10d0\u10e4\u10d0\u10dc\u10e2\u10e3\u10da\u10d8 \u10e1\u10d9\u10da\u10d4\u10e0\u10dd\u10d6\u10d8\u10e1 (MS) \u10de\u10d0\u10d7\u10dd\u10d2\u10d4\u10dc\u10d4\u10d6\u10e1. \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10d2\u10d6\u10d4\u10d1\u10d8 \u10db\u10d8\u10d7\u10d8\u10d7\u10d4\u10d1\u10e3\u10da\u10d8\u10d0, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10d0\u10ee\u10d0\u10da\u10d8 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da\u10d8 \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4\u10d4\u10d1\u10d8 \u10d0\u10db \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1. \u10db\u10d0\u10e1\u10e2\u10dd\u10d8\u10d3\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8 \u10f0\u10d4\u10db\u10d0\u10e2\u10dd\u10de\u10dd\u10d4\u10e2\u10e3\u10e0\u10d8 \u10ec\u10d0\u10e0\u10db\u10dd\u10e8\u10dd\u10d1\u10d8\u10e1 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10d0, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10e0\u10d4\u10d2\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d4\u10dc \u10d0\u10dc\u10d7\u10d4\u10d1\u10d0\u10e1 \u10d3\u10d0 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10d2\u10d0\u10db\u10dd\u10e3\u10e8\u10d5\u10d4\u10d1\u10d4\u10dc \u10d1\u10d4\u10d5\u10e0 \u10de\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10e1, \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d3\u10d0 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10dc\u10d4\u10e0\u10d5\u10e3\u10da\u10d8 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d8\u10e1 (\u10ea\u10dc\u10e1) \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10de\u10d8\u10e0\u10dd\u10d1\u10d4\u10d1\u10e8\u10d8. \u10d2\u10d0\u10e0\u10d3\u10d0 \u10d0\u10db\u10d8\u10e1\u10d0, \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d2\u10da\u10d8\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10d3\u10d0\u10dc \u10d2\u10d0\u10db\u10dd\u10d7\u10d0\u10d5\u10d8\u10e1\u10e3\u10e4\u10da\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0\u10e1 \u10d8\u10ec\u10d5\u10d4\u10d5\u10d4\u10dc. \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10d2\u10d0\u10db\u10dd\u10ec\u10d5\u10d4\u10e3\u10da\u10d8 \u10de\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10ea\u10d8\u10e2\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10d8\/\u10e5\u10d8\u10db\u10d8\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 \u10d8\u10ec\u10d5\u10d4\u10d5\u10d4\u10dc \u10e1\u10d8\u10e1\u10ee\u10da\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10d1\u10d0\u10e0\u10d8\u10d4\u10e0\u10d8\u10e1 (BBB) \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d0\u10e1, \u10e0\u10d0\u10ea \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8\/\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1, \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1, \u10db\u10d0\u10e1\u10e2\u10dd\u10d8\u10d3\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10db\u10dd\u10e0\u10d1\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1, \u10db\u10d0\u10e1\u10e2\u10dd\u10d8\u10d3\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0 \u10de\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10ea\u10d8\u10e2\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e5\u10d8\u10db\u10d8\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 \u10e8\u10d4\u10e7\u10d5\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d0\u10e1 \u10d8\u10eb\u10da\u10d4\u10d5\u10d0. \u10d0\u10db \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10ec\u10d0\u10e0\u10db\u10dd\u10e8\u10dd\u10d1\u10d8\u10e1 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10db\u10d0 \u10d3\u10d0 \u10e8\u10d8\u10dc\u10d0\u10d2\u10d0\u10dc\u10d0\u10d3 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d8\u10da\u10db\u10d0 \u10ea\u10d8\u10e2\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10db\u10d0\/\u10e5\u10d4\u10db\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10db\u10d0, \u03b1-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10db\u10d0, \u10d9\u10dd\u10e0\u10e2\u10d8\u10d9\u10dd\u10e2\u10e0\u10dd\u10de\u10d8\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10db\u10e7\u10dd\u10e4\u10db\u10d0 \u10f0\u10dd\u10e0\u10db\u10dd\u10dc\u10db\u10d0 (CRH), P \u10dc\u10d8\u10d5\u10d7\u10d8\u10d4\u10e0\u10d4\u10d1\u10d0\u10db (SP), \u10d1\u10d4\u10e2\u10d0 \u10d0\u10db\u10d8\u10da\u10dd\u10d8\u10d3\u10e3\u10e0\u10db\u10d0 1-42 (A\u03b21-42) \u10de\u10d4\u10de\u10e2\u10d8\u10d3\u10db\u10d0 \u10d3\u10d0 \u10d0\u10db\u10d8\u10da\u10dd\u10d8\u10d3\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10db\u10dd\u10e0\u10d1\u10d4\u10d3\u10db\u10d0 \u10ea\u10d8\u10da\u10d4\u10d1\u10db\u10d0 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10dd\u10dc \u10d2\u10da\u10d8\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8, \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 T- \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1 \u10d3\u10d0 \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10e1 \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0\u10d7 \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10dd\u10dc \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10e2\u10dd\u10e5\u10e1\u10d8\u10e3\u10e0\u10d8 \u10db\u10dd\u10da\u10d4\u10d9\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10db\u10d0\u10e2\u10d4\u10d1\u10d8\u10d7 \u10d2\u10d0\u10db\u10dd\u10e7\u10dd\u10e4\u10d0, \u10e0\u10d0\u10ea \u10ee\u10d4\u10da\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1 \u10e5\u10e0\u10dd\u10dc\u10d8\u10d9\u10e3\u10da \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0\u10e1 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d8\u10d9\u10d5\u10d3\u10d8\u10da\u10e1. \u10d2\u10da\u10d8\u10d8\u10e1 \u10db\u10dd\u10db\u10ec\u10d8\u10e4\u10d4\u10d1\u10d8\u10e1 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8 (GMF), \u10de\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10ea\u10d8\u10da\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10e9\u10d5\u10d4\u10dc\u10e1 \u10da\u10d0\u10d1\u10dd\u10e0\u10d0\u10e2\u10dd\u10e0\u10d8\u10d0\u10e8\u10d8 \u10d8\u10e5\u10dc\u10d0 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d8\u10da\u10d8, \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10dd\u10e4\u10d0 \u10e0\u10d0 \u10d2\u10da\u10d8\u10d8\u10d3\u10d0\u10dc, \u10d0\u10ee\u10d3\u10d4\u10dc\u10e1 \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d0\u10e1, \u10e0\u10d0\u10d7\u10d0 \u10d2\u10d0\u10db\u10dd\u10e3\u10e8\u10d5\u10d0\u10e1 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10ea\u10d8\u10e2\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e5\u10d4\u10db\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10d8. \u10e5\u10e0\u10dd\u10dc\u10d8\u10d9\u10e3\u10da\u10d8 \u10d6\u10e0\u10d3\u10d0 \u10de\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10e8\u10d8, \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10e2\u10dd\u10e5\u10e1\u10d8\u10d9\u10e3\u10e0\u10d8 A\u03b2-\u10d8\u10e1 \u10d3\u10d0 \u10e4\u10dd\u10da\u10d0\u10e5\u10d8\u10e1 \u10e4\u10dd\u10e0\u10db\u10d8\u10e0\u10d4\u10d1\u10d0 AD \u10e2\u10d5\u10d8\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0\u10e1 PD \u10e2\u10d5\u10d8\u10dc\u10d4\u10d1\u10e8\u10d8. \u10d2\u10da\u10d8\u10e3\u10e0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1, \u10db\u10d0\u10e1\u10e2 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1\u10d0 \u10d3\u10d0 T-\u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1 \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0\u10d7 \u10d4\u10e0\u10d7\u10db\u10d0\u10dc\u10d4\u10d7\u10d8\u10e1 \u10e0\u10d4\u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d0 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10d3\u10d0 \u10d2\u10d0\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10dd\u10dc \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0. \u10e9\u10d5\u10d4\u10dc \u10d5\u10e4\u10d8\u10e5\u10e0\u10dd\u10d1\u10d7, \u10e0\u10dd\u10db \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d7\u10d0\u10dc \u10d0\u10e1\u10dd\u10ea\u10d8\u10e0\u10d4\u10d1\u10e3\u10da \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10e1 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e2\u10d5\u10d8\u10dc\u10d8\u10d3\u10d0\u10dc \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0\u10d7 \u10d2\u10d0\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10dd\u10dc \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0. \u10d4\u10e1 \u10db\u10d8\u10db\u10dd\u10ee\u10d8\u10da\u10d5\u10d8\u10d7\u10d8 \u10e1\u10e2\u10d0\u10e2\u10d8\u10d0 \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d8\u10d0 \u10d6\u10dd\u10d2\u10d8\u10d4\u10e0\u10d7\u10d8 \u10d0\u10e2\u10d8\u10de\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d8\u10e1 \u10e0\u10dd\u10da\u10d8\u10e1\u10d9\u10d4\u10dc, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10e1\u10dd\u10ea\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10e3\u10e0 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0 \u10db\u10d0\u10d7 \u10db\u10d8\u10d4\u10e0 \u10d2\u10da\u10d8\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d0\u10e1\u10d7\u10d0\u10dc, \u10e0\u10d0\u10d7\u10d0 \u10db\u10dd\u10d0\u10ee\u10d3\u10d8\u10dc\u10dd\u10dc \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d8\u10dc\u10d3\u10e3\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0.<\/p>\n\n\n\n<p><strong>\u10e1\u10d0\u10d9\u10d5\u10d0\u10dc\u10eb\u10dd \u10e1\u10d8\u10e2\u10e7\u10d5\u10d4\u10d1\u10d8:<\/strong> \u10e2\u10d5\u10d8\u10dc\u10d8, \u10ea\u10d8\u10e2\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e5\u10d4\u10db\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10d8, \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8, \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8, \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0, \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><a><\/a><strong>\u10e8\u10d4\u10e1\u10d0\u10d5\u10d0\u10da\u10d8<\/strong><strong><\/strong><\/h1>\n\n\n\n<p>&nbsp;&nbsp; \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d0\u10e0\u10d8\u10e1 \u10db\u10d0\u10e1\u10de\u10d8\u10dc\u10eb\u10da\u10d8\u10e1 \u10d7\u10d0\u10d5\u10d3\u10d0\u10ea\u10d5\u10d8\u10d7\u10d8 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d8\u10ea\u10d0\u10d5\u10e1 \u10d3\u10d0 \u10d0\u10e6\u10d0\u10d3\u10d2\u10d4\u10dc\u10e1 \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10dc\u10dd\u10e0\u10db\u10d0\u10da\u10e3\u10e0 \u10e1\u10e2\u10e0\u10e3\u10e5\u10e2\u10e3\u10e0\u10d0\u10e1 \u10d3\u10d0 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d0\u10e1 \u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0 \u10d3\u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10d4\u10d1\u10d0\u10e8\u10d8 (More et al., 2013). \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10e8\u10d8, \u10dc\u10d4\u10d8\u10e0\u10dd\u10d8\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d7\u10d0\u10d5\u10d3\u10d0\u10de\u10d8\u10e0\u10d5\u10d4\u10da\u10d0\u10d3 \u10d0\u10e8\u10dd\u10e0\u10d4\u10d1\u10e1 \u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10d0\u10e1, \u10e0\u10d0\u10d7\u10d0 \u10d2\u10d0\u10d0\u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10dd\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d8\u10db\u10eb\u10d8\u10db\u10d4 \u10d3\u10d0 \u10de\u10e0\u10dd\u10d2\u10e0\u10d4\u10e1\u10d8. \u10d7\u10e3\u10db\u10ea\u10d0, \u10dc\u10d4\u10d8\u10e0\u10dd\u10d8\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10e1 \u10dd\u10e0\u10db\u10d0\u10d2\u10d8 \u10db\u10d0\u10ee\u10d5\u10d8\u10da\u10d8\u10d5\u10d8\u10d7 (Kielian, 2016). \u10d4\u10e0\u10d7\u10d8 \u10db\u10ee\u10e0\u10d8\u10d5, \u10dc\u10d4\u10d8\u10e0\u10dd\u10d8\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10d3\u10d0\/\u10d0\u10dc \u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d4\u10d1\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0\u10e1 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10da\u10e3\u10e0 \u10dc\u10d4\u10e0\u10d5\u10e3\u10da \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d0\u10e8\u10d8 (\u10ea\u10dc\u10e1), \u10ee\u10dd\u10da\u10dd \u10db\u10d4\u10dd\u10e0\u10d4 \u10db\u10ee\u10e0\u10d8\u10d5 &#8211; \u10ee\u10d4\u10da\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1 \u10d3\u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e6\u10d3\u10d2\u10d4\u10dc\u10d0\u10e1 (Lucas et al., 2006). \u10e3\u10d0\u10ee\u10da\u10d4\u10e1\u10db\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d2\u10d0\u10e0\u10d9\u10d5\u10d4\u10e3\u10da\u10ec\u10d8\u10da\u10d0\u10d3 \u10e0\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1 \u10ee\u10d4\u10da\u10e1 (<a href=\"#_bookmark21\">Bollaerts et al.<\/a>, <a href=\"#_bookmark21\">2017<\/a>). \u10e5\u10e0\u10dd\u10dc\u10d8\u10d9\u10e3\u10da\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10ea\u10d8\u10e2\u10dd\u10e2\u10dd\u10e5\u10e1\u10d8\u10d9\u10e3\u10e0 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d4\u10d1\u10e1 \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10d3\u10d0 \u10d6\u10e0\u10d3\u10d8\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d8\u10db\u10eb\u10d8\u10db\u10d4\u10e1. \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d0\u10e0\u10d8\u10e1 \u10d3\u10d0\u10db\u10d0\u10dc\u10d2\u10e0\u10d4\u10d5\u10d4\u10da\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10ec\u10d0\u10db\u10e7\u10d5\u10d0\u10dc\u10d8 \u10db\u10d8\u10d6\u10d4\u10d6\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d4\u10d1\u10d8\u10ea\u10d0\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0 (PD), \u10d0\u10da\u10ea\u10f0\u10d4\u10d8\u10db\u10d4\u10e0\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0 (AD), \u10d0\u10db\u10d8\u10dd\u10e2\u10e0\u10dd\u10e4\u10d8\u10e3\u10da\u10d8 \u10d2\u10d5\u10d4\u10e0\u10d3\u10d8\u10d7\u10d8 \u10e1\u10d9\u10da\u10d4\u10e0\u10dd\u10d6\u10d8 (ALS) \u10d3\u10d0 \u10d2\u10d0\u10e4\u10d0\u10dc\u10e2\u10e3\u10da\u10d8 \u10e1\u10d9\u10da\u10d4\u10e0\u10dd\u10d6\u10d8 (MS) \/ \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10d0\u10e3\u10e2\u10dd\u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10d4\u10dc\u10ea\u10d4\u10e4\u10d0\u10da\u10dd\u10db\u10d8\u10d4\u10da\u10d8\u10e2\u10d8 (Chen et al., 2016; Kempuraj et al., 2016b). \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d2\u10da\u10d8\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8 \u10e3\u10e8\u10d5\u10d4\u10d1\u10d4\u10dc \u10e0\u10d0\u10db\u10d3\u10d4\u10dc\u10d8\u10db\u10d4 \u10de\u10e0\u10dd-\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10ea\u10d8\u10e2\u10dd\u10d9\u10d8\u10dc\u10e1, \u10e5\u10d4\u10db\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10e1 \u10d3\u10d0 \u10df\u10d0\u10dc\u10d2\u10d1\u10d0\u10d3\u10d8\u10e1 \u10e0\u10d4\u10d0\u10e5\u10e2\u10d8\u10e3\u10da \u10e1\u10d0\u10ee\u10d4\u10dd\u10d1\u10d0\u10e1 (ROS), \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10d2\u10d0\u10db\u10dd\u10ec\u10d5\u10d4\u10e3\u10da\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d4\u10d1\u10e1 \u10e8\u10e3\u10d0\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d4\u10dc (Kempuraj et al., 2016b). \u10db\u10d0\u10e0\u10d4\u10d2\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d4\u10da\u10d8 T \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10d4\u10e0 \u10d2\u10d0\u10db\u10dd\u10e7\u10dd\u10e4\u10d8\u10da\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10de\u10d4\u10de\u10e2\u10d8\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10d4\u10e0 \u10e1\u10d8\u10dc\u10d7\u10d4\u10d6\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10ea\u10d8\u10e2\u10dd\u10d9\u10d8\u10dc\u10d4\u10d1\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1\u10d2\u10d0\u10dc \u10d8\u10ea\u10d0\u10d5\u10d4\u10dc, \u10e0\u10d0\u10ea \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10e1\u10e3\u10d1\u10e3\u10e5\u10d4\u10d1\u10d0\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1 \u10ee\u10d4\u10da\u10e1. \u10d1\u10dd\u10da\u10dd\u10d3\u10e0\u10dd\u10d8\u10dc\u10d3\u10d4\u10da\u10d8 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d0 \u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10db\u10e3\u10dc\u10e3\u10e0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1, \u10d2\u10da\u10d8\u10e3\u10e0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1\u10d0 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10e3\u10da \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1 \u10db\u10dd\u10d8\u10ea\u10d0\u10d5\u10d4\u10dc, \u10eb\u10d0\u10da\u10d8\u10d0\u10dc \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d3\u10d0 \u10e4\u10e3\u10dc\u10d3\u10d0\u10db\u10d4\u10dc\u10e2\u10e3\u10e0\u10d8\u10d0 \u10d8\u10e1\u10d4\u10d7\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e8\u10dd\u10d1\u10d8\u10e1 \u10d0\u10dc \u10de\u10d0\u10d7\u10dd\u10d2\u10d4\u10dc\u10d4\u10d6\u10d8\u10e1 \u10d2\u10d0\u10e1\u10d0\u10d2\u10d4\u10d1\u10d0\u10d3, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10d3\u10dd\u10e4\u10d0\u10db\u10d8\u10dc\u10d4\u10e0\u10d2\u10e3\u10da\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10dd\u10d2\u10e0\u10d4\u10e1\u10d8\u10e0\u10d4\u10d1\u10d0\u10d3\u10d8 \u10d3\u10d0\u10e6\u10e3\u10de\u10d5\u10d0 PD-\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 (Chung et al., 2010; More et al., 2013; Kong et al., 2017; Visan, 2017). \u10d2\u10d0\u10e0\u10d3\u10d0 \u10d0\u10db\u10d8\u10e1\u10d0, \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10e0\u10d0\u10db\u10d3\u10d4\u10dc\u10d8\u10db\u10d4 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8\u10e1 \u10db\u10d4\u10e8\u10d5\u10d4\u10dd\u10d1\u10d8\u10d7 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d4\u10d1\u10e1 \u10d6\u10e0\u10d3\u10d8\u10e1 (Machado et al., 2011; Hern\u00e1ndez-Romero et al., 2012; Takeda et al., 2013). \u10ec\u10d8\u10dc\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10db\u10d0 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db \u10d0\u10e0\u10d0\u10e1\u10e2\u10d4\u10e0\u10dd\u10d8\u10d3\u10e3\u10da\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8 (NSAIDs), \u10e1\u10e2\u10d0\u10e2\u10d8\u10dc\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d4\u10d1\u10d8 \u10d2\u10d0\u10e0\u10d9\u10d5\u10d4\u10e3\u10da\u10d0\u10d3 \u10d0\u10db\u10e1\u10e3\u10d1\u10e3\u10e5\u10d4\u10d1\u10e1 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d0\u10e1, \u10d7\u10e3\u10db\u10ea\u10d0 \u10d8\u10e1\u10d8\u10dc\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 \u10d0\u10e0\u10d0\u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10d8\u10d0 (Szekely and Zandi, 2010; Lehrer, 2014; Kure et al., 2017). \u10d4\u10e1 \u10d8\u10db\u10d8\u10e2\u10dd\u10db \u10ee\u10d3\u10d4\u10d1\u10d0, \u10e0\u10dd\u10db \u10d0\u10e0\u10d0\u10e1\u10e2\u10d4\u10e0\u10dd\u10d8\u10d3\u10e3\u10da\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10d0\u10d3 \u10d0\u10e0 \u10d9\u10d5\u10d4\u10d7\u10d4\u10dc \u10f0\u10d4\u10db\u10d0\u10e2\u10dd\u10d4\u10dc\u10ea\u10d4\u10e4\u10d0\u10da\u10e3\u10e0 \u10d1\u10d0\u10e0\u10d8\u10d4\u10e0\u10e1 (BBB) \u10d3\u10d0 \u10d0\u10e0 \u10d0\u10e6\u10ec\u10d4\u10d5\u10d4\u10dc \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da \u10d3\u10dd\u10dc\u10d4\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10eb\u10da\u10d4\u10d5\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e3\u10d9\u10e3\u10e5\u10ea\u10d4\u10d5\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1. \u10d0\u10db\u10d2\u10d5\u10d0\u10e0\u10d0\u10d3, \u10e8\u10d4\u10db\u10dd\u10d7\u10d0\u10d5\u10d0\u10d6\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da\u10d8 \u10d5\u10d0\u10e0\u10d8\u10d0\u10dc\u10e2\u10d4\u10d1\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10ea\u10ee\u10d5\u10d8\u10e0\u10d8\u10e1 NSAID-\u10d4\u10d1\u10d8, \u10e0\u10d0\u10d7\u10d0 \u10d2\u10d0\u10d0\u10e3\u10db\u10ef\u10dd\u10d1\u10d4\u10e1\u10dd\u10dc \u10db\u10d8\u10e1\u10d8 \u10d1\u10d8\u10dd\u10e8\u10d4\u10e6\u10ec\u10d4\u10d5\u10d0\u10d3\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7, \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 \u10d9\u10dd\u10dc\u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d8\u10d7 (Lehrer, 2014).<\/p>\n\n\n\n<p>\u10e2\u10d5\u10d8\u10dc\u10e1\u10d0 \u10d3\u10d0 \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da \u10d8\u10db\u10e3\u10dc\u10e3\u10e0 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d0\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10dd\u10e0\u10db\u10ee\u10e0\u10d8\u10d5\u10d8 \u10d9\u10dd\u10db\u10e3\u10dc\u10d8\u10d9\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10d0 \u10d1\u10dd\u10da\u10dd \u10dd\u10e0\u10d8 \u10d0\u10d7\u10ec\u10da\u10d4\u10e3\u10da\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8\u10d0 \u10ea\u10dc\u10dd\u10d1\u10d8\u10da\u10d8 (Johnson et al., 1997; Dantzer et al., 2000; Holmes and Butchart, 2011; Hern\u00e1ndez-Romero et al., 2012; McCusker and Kelley, 2013; Tr\u00e4ger and Tabrizi, 2013; Engelhardt et al., 2017). \u10ea\u10dc\u10dd\u10d1\u10d8\u10da\u10d8\u10d0, \u10e0\u10dd\u10db \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10de\u10d8\u10e0\u10d3\u10d0\u10de\u10d8\u10e0 \u10d3\u10d0 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d0\u10d3 \u10ee\u10d4\u10da\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1 \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d4\u10d9\u10e0\u10e3\u10e2\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1 \u10d3\u10d0 \u10d6\u10e0\u10d3\u10d8\u10e1 BBB \u10d2\u10d0\u10db\u10e2\u10d0\u10e0\u10d8\u10d0\u10dc\u10dd\u10d1\u10d0\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 (Hayley and Anisman, 2005; Ferrari and Tarelli, 2011; Espinosa-Oliva et al., 2014; Dendrou et al., 2016; McManus and Heneka, 2017; Schain and Kreisl, 2017). \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10d0 \u10d3\u10d0 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d6\u10e0\u10d3\u10d8\u10e1 BBB-\u10d8\u10e1 \u10d2\u10d0\u10db\u10e2\u10d0\u10e0\u10d8\u10d0\u10dc\u10dd\u10d1\u10d0\u10e1 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0\u10e1 AD-\u10d8\u10e1 \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10e3\u10e0 \u10db\u10dd\u10d3\u10d4\u10da\u10e8\u10d8 (Takeda et al., 2013). \u10d0\u10e1\u10d4\u10d5\u10d4, \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d0\u10e1 \u10d0\u10ee\u10d3\u10d4\u10dc\u10e1 \u10f0\u10d8\u10de\u10dd\u10d9\u10d0\u10db\u10de\u10d6\u10d4 \u10d3\u10d0\u10db\u10dd\u10d9\u10d8\u10d3\u10d4\u10d1\u10e3\u10da \u10db\u10d4\u10ee\u10e1\u10d8\u10d4\u10e0\u10d4\u10d1\u10d0\u10d6\u10d4 (Culley et al., 2014; Takeda et al., 2014). \u10db\u10d8\u10d9\u10e0\u10dd\u10d2\u10da\u10d8\u10d0, \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10db\u10d0\u10d9\u10e0\u10dd\u10e4\u10d0\u10d2\u10d8, \u10d7\u10d0\u10dc\u10d3\u10d0\u10e7\u10dd\u10da\u10d8\u10da\u10d8 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10e0\u10d4\u10d6\u10d8\u10d3\u10d4\u10dc\u10e2\u10d8\u10d0 \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8. \u10db\u10d8\u10d9\u10e0\u10dd\u10d2\u10da\u10d8\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10d0 \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10db\u10d0\u10d7 \u10d2\u10d0\u10db\u10e0\u10d0\u10d5\u10da\u10d4\u10d1\u10d0\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10de\u10d8\u10e0\u10dd\u10d1\u10d4\u10d1\u10e8\u10d8 (Perry et al., 2010; Perry, 2016). \u10d2\u10d0\u10e0\u10d3\u10d0 \u10d0\u10db\u10d8\u10e1\u10d0, \u10d0\u10e1\u10e2\u10e0\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8, \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8, \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10de\u10d4\u10e0\u10d8\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8, T \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc \u10e0\u10dd\u10da\u10e1 \u10d0\u10e1\u10e0\u10e3\u10da\u10d4\u10d1\u10d4\u10dc \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d4\u10d1\u10e8\u10d8. \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8, \u10dc\u10d4\u10d8\u10e0\u10dd\u10e2\u10dd\u10e5\u10e1\u10d8\u10e3\u10e0\u10d8 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8, \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10f0\u10dd\u10e0\u10db\u10dd\u10dc\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d2\u10da\u10d8\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0 \u10d3\u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10d4\u10e0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10dd\u10e4\u10d0, AD \u10d3\u10d0 PD \u10de\u10d0\u10d7\u10dd\u10d2\u10d4\u10dc\u10d4\u10d6\u10e8\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0\u10e8\u10d8 \u10db\u10dd\u10dc\u10d0\u10ec\u10d8\u10da\u10d4\u10dd\u10d1\u10d4\u10dc (Tufekci et al., 2012; Pennisi et al., 2016; <a href=\"#_bookmark15\">Becher<\/a> <a href=\"#_bookmark15\">et al.<\/a>, <a href=\"#_bookmark15\">2017<\/a>; Gualtierotti et al., 2017; Rustenhoven et al., 2017; Sawikr et al., 2017; Song et al., 2017). \u10e8\u10d0\u10d5 \u10e1\u10e3\u10d1\u10e1\u10e2\u10d0\u10dc\u10ea\u10d8\u10d0\u10e1 \u10db\u10d8\u10d9\u10e0\u10dd\u10d2\u10da\u10d8\u10e3\u10e0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10e7\u10d5\u10d4\u10da\u10d0\u10d6\u10d4 \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10e1\u10d8\u10db\u10d9\u10d5\u10e0\u10d8\u10d5\u10d4 \u10d0\u10e5\u10d5\u10e1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d8\u10da\u10d8\u10d0 PD-\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8. AD-\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1, \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d8\u10d9\u10e0\u10dd\u10d2\u10da\u10d8\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8 \u10d1\u10d4\u10e2\u10d0-\u10d0\u10db\u10d8\u10da\u10dd\u10d8\u10d3\u10e3\u10e0\u10d8 (A\u03b2) \u10d3\u10d0\u10e4\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10e0\u10e8\u10d4\u10db\u10dd \u10d2\u10d5\u10ee\u10d5\u10d3\u10d4\u10d1\u10d0. \u10db\u10d8\u10d9\u10e0\u10dd\u10d2\u10da\u10d8\u10e3\u10e0\u10d8 \u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d0 \u10d3\u10d0 \u10db\u10d8\u10d9\u10e0\u10dd\u10d2\u10da\u10d8\u10e3\u10e0\u10d8 \u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10d7\u10e0\u10d2\u10e3\u10dc\u10d5\u10d0 \u10db\u10ed\u10d8\u10d3\u10e0\u10dd\u10d3 \u10e0\u10d4\u10d2\u10e3\u10da\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 \u10db\u10e0\u10d0\u10d5\u10d0\u10da\u10d8 \u10db\u10d8\u10d9\u10e0\u10dd\u10e0\u10dc\u10db-\u10d8\u10d7, \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10db\u10d0\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10db\u10d8\u10e0-155 \u10d3\u10d0 \u10db\u10d8\u10e0-204, \u10d0\u10e1\u10d4\u10d5\u10d4, \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10db\u10d8\u10e0-203, \u10db\u10d8\u10e0-181c \u10d3\u10d0 \u10db\u10d8\u10e0-424-\u10d8\u10d7 (<a href=\"#_bookmark27\">Cardoso<\/a> <a href=\"#_bookmark27\">et al.<\/a>, <a href=\"#_bookmark27\">2012<\/a>; Li L. et al., 2015). \u10ea\u10dd\u10e2\u10d0 \u10ee\u10dc\u10d8\u10e1 \u10ec\u10d8\u10dc, \u10d7\u10d0\u10d2\u10d5\u10d8\u10e1 PD \u10db\u10dd\u10d3\u10d4\u10da\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db 1-\u10db\u10d4\u10d7\u10d8\u10da-4-\u10e4\u10d4\u10dc\u10d8\u10da-1,2,3,6-\u10e2\u10d4\u10e2\u10e0\u10d0\u10f0\u10d8\u10d3\u10e0\u10dd\u10de\u10d8\u10e0\u10d8\u10d3\u10d8\u10dc\u10d8\u10e1 (MPTP) \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10d7 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db 1-\u10db\u10d4\u10d7\u10d8\u10da-4-\u10e4\u10d4\u10dc\u10d8\u10da\u10de\u10d8\u10e0\u10d8\u10d3\u10d8\u10dc\u10d8\u10e3\u10db\u10d8 (MPP+) \u10d0\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10e1 \u10db\u10d8\u10e0-7116-5p-\u10e1 \u10db\u10d8\u10d9\u10e0\u10dd\u10d2\u10da\u10d8\u10d0\u10e8\u10d8 \u10d3\u10d0 \u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d4\u10d1\u10e1 TNF-\u03b1 \u10ec\u10d0\u10e0\u10db\u10dd\u10d4\u10d1\u10d0\u10e1 \u10d3\u10d0 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d4\u10d1\u10e1, \u10e0\u10d0\u10ea \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 DA \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10d0\u10e1 (He et al., 2017).<\/p>\n\n\n\n<p>\u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10d7\u10d0\u10dc\u10d3\u10d0\u10e7\u10dd\u10da\u10d8\u10da\u10d8 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d3\u10d0, \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10d7\u10d0\u10dc\u10d3\u10d0\u10e7\u10dd\u10da\u10d8\u10da\u10d8 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d8\u10e1 \u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d0 \u10d0\u10e6\u10d8\u10d0\u10e0\u10d4\u10d1\u10e3\u10da\u10d8\u10d0, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10d2\u10d0\u10db\u10dd\u10e0\u10e9\u10d4\u10e3\u10da\u10d8 \u10d7\u10d5\u10d8\u10e1\u10d4\u10d1\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10dd\u10d2\u10e0\u10d4\u10e1\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1 \u10ee\u10d4\u10da\u10e1 (Tr\u00e4ger and Tabrizi, 2013). \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d0\u10db\u10eb\u10d0\u10e4\u10e0\u10d4\u10d1\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10e1, \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d0\u10e1 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d8\u10d9\u10d5\u10d3\u10d8\u10da\u10e1 \u10ee\u10d0\u10dc\u10d3\u10d0\u10d6\u10db\u10e3\u10da \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d3\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e1\u10d0\u10ea \u10d2\u10d0\u10d3\u10d0\u10e2\u10d0\u10dc\u10d8\u10da\u10d8 \u10d0\u10e5\u10d5\u10d7 \u10d8\u10dc\u10e1\u10e3\u10da\u10e2\u10d8 \u10d3\u10d0 \u10e5\u10e0\u10dd\u10dc\u10d8\u10d9\u10e3\u10da\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0 (Teeling and Perry, 2009). \u10db\u10dd\u10ee\u10e1\u10d4\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd, \u10e0\u10dd\u10db \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10d0 \u10d3\u10d0 \u10d2\u10d0\u10d6\u10e0\u10d3\u10d8\u10da\u10d8 IL-1\u03b2 \u10d8\u10ec\u10d5\u10d4\u10d5\u10d4\u10dc \u10d9\u10dd\u10d2\u10dc\u10d8\u10e2\u10e3\u10e0 \u10d3\u10d0\u10e5\u10d5\u10d4\u10d8\u10d7\u10d4\u10d1\u10d0\u10e1 AD \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 (Holmes et al., 2003). \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d0\u10e1 \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0 \u10db\u10dd\u10d0\u10ee\u10d3\u10d8\u10dc\u10dd\u10e1 \u10e5\u10ea\u10d4\u10d5\u10d8\u10d7\u10d8 \u10d3\u10d0 \u10d9\u10dd\u10d2\u10dc\u10d8\u10ea\u10d8\u10e3\u10e0\u10d8 \u10ea\u10d5\u10da\u10d8\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d8\u10dc\u10d3\u10e3\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10de\u10d0\u10d7\u10dd\u10d2\u10d4\u10dc\u10d4\u10d6\u10d8\u10e1 \u10d3\u10d0\u10e9\u10e5\u10d0\u10e0\u10d4\u10d1\u10d0 (Perry, 2004; Perry et al., 2007; Cunningham et al., 2009). \u10d0\u10e5\u10e2\u10d8\u10d5\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10ed\u10d0\u10e0\u10d1\u10d8 \u10d0\u10d9\u10e3\u10db\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d0 \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 \u10d9\u10d0\u10e0\u10d2\u10d0\u10d3\u10d0\u10d0 \u10d3\u10dd\u10d9\u10e3\u10db\u10d4\u10dc\u10e2\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10db\u10dd\u10d8\u10ea\u10d0\u10d5\u10d4\u10dc \u10db\u10e0\u10d0\u10d5\u10da\u10dd\u10d1\u10d8\u10d7 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0\u10e1. \u10de\u10da\u10d0\u10d6\u10db\u10d0\u10e8\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d8\u10e1 \u10d3\u10dd\u10dc\u10d4\u10d4\u10d1\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10de\u10d8\u10e0\u10dd\u10d1\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10d8\u10db\u10d0\u10e2\u10d4\u10d1\u10e1. \u10d0\u10db\u10d2\u10d5\u10d0\u10e0\u10d0\u10d3, \u10ea\u10d8\u10e2\u10dd\u10d9\u10d8\u10dc\u10d8\u10e1 \u10d3\u10dd\u10dc\u10d4\u10d4\u10d1\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da \u10d8\u10e5\u10dc\u10d0\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d1\u10d8\u10dd\u10db\u10d0\u10e0\u10d9\u10d4\u10e0\u10d0\u10ea, PD-\u10d8\u10e1 \u10e9\u10d0\u10d7\u10d5\u10da\u10d8\u10d7 (Litteljohn and Hayley, 2012). \u10ea\u10d8\u10e2\u10dd\u10d9\u10d8\u10dc\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e5\u10d4\u10db\u10dd\u10d9\u10d8\u10dc\u10d8\u10e1 \u10d3\u10dd\u10dc\u10d4\u10d4\u10d1\u10d8 \u10d9\u10dd\u10e0\u10d4\u10da\u10d8\u10e0\u10d4\u10d1\u10e1 \u10d7\u10d0\u10d5\u10d6\u10e3\u10e0\u10d2\u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10e1\u10d8\u10d7\u10ee\u10d4\u10e1\u10d0 (CSF) \u10d3\u10d0 \u10de\u10da\u10d0\u10d6\u10db\u10d0\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 AD-\u10d8\u10e1\u10d0 (Sun et al., 2003) \u10d3\u10d0 PD-\u10d8\u10e1 (<a href=\"#_bookmark20\">Blum-Degen et al.<\/a>, <a href=\"#_bookmark20\">1995<\/a>) \u10d3\u10e0\u10dd\u10e1. \u10d4\u10e1 \u10db\u10d8\u10e3\u10d7\u10d8\u10d7\u10d4\u10d1\u10e1 \u10d8\u10db\u10d0\u10d6\u10d4, \u10e0\u10dd\u10db \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10e1\u10d0 \u10d3\u10d0 \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10d0\u10e8\u10d8 \u10d0\u10d3\u10d2\u10d8\u10da\u10d8 \u10d0\u10e5\u10d5\u10e1 \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d8 \u10e2\u10d8\u10de\u10d8\u10e1 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0 \u10de\u10d0\u10e1\u10e3\u10ee\u10d4\u10d1\u10e1, \u10d3\u10d0 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10e1 \u10d9\u10dd\u10db\u10e3\u10dc\u10d8\u10d9\u10d0\u10ea\u10d8\u10d0\u10e1 \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da \u10d8\u10db\u10e3\u10dc\u10e3\u10e0 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d4\u10d1\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1. \u10e1\u10d0\u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10dd \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10db\u10dd\u10d0\u10ee\u10d3\u10d8\u10dc\u10d0 \u10d3\u10d4\u10db\u10dd\u10dc\u10e1\u10e2\u10e0\u10d8\u10e0\u10d4\u10d1\u10d0, \u10e0\u10dd\u10db \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10d1\u10d8\u10e0\u10d7\u10d5\u10e3\u10da\u10d8 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8\u10e1 \u10d9\u10d0\u10de\u10de\u10d0-\u10d1-\u10d8\u10e1 (NF-\u03baB) \u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d6\u10d4\u10e0\u10d4\u10d2\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d0 \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10e1\u10d8\u10e1\u10ee\u10da\u10d8\u10e1 \u10db\u10dd\u10dc\u10dd\u10dc\u10e3\u10d9\u10da\u10d4\u10d0\u10e0\u10e3\u10da \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e8\u10d8 \u10d2\u10d5\u10d0\u10db\u10ea\u10dc\u10dd\u10d1\u10e1, \u10e0\u10dd\u10db \u10d0\u10d3\u10d2\u10d8\u10da\u10d8 \u10d0\u10e5\u10d5\u10e1 NF-\u03baB \u10d8\u10dc\u10f0\u10d8\u10d1\u10d8\u10e2\u10dd\u10e0\u10d4\u10d1\u10e1 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da\u10d8 \u10d0\u10d2\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ee\u10d8\u10d7 AD-\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 (<a href=\"#_bookmark13\">Ascolani et al.<\/a>, <a href=\"#_bookmark13\">2012<\/a>). \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 T \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e5\u10d5\u10d4\u10dc\u10d0\u10d9\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d8\u10e1\u10d1\u10d0\u10da\u10d0\u10dc\u10e1\u10d8 (\u10d3\u10d0\u10e5\u10d5\u10d4\u10d8\u10d7\u10d4\u10d1\u10e3\u10da\u10d8 CD8+ \u10d3\u10d0 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10e3\u10da\u10d8 CD4+ \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8) \u10db\u10dd\u10ee\u10e1\u10d4\u10dc\u10d4\u10d1\u10e3\u10da \u10d8\u10e5\u10dc\u10d0 AD-\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10d0\u10ea \u10db\u10d8\u10e3\u10d7\u10d8\u10d7\u10d4\u10d1\u10e1 \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da \u10d8\u10db\u10e3\u10dc\u10e3\u10e0 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d0\u10d6\u10d4 AD-\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 (Shalit et al., 1995); \u10d4\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d8\u10d0 \u10ec\u10d8\u10dc\u10d0 \u10db\u10dd\u10ee\u10e1\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10e1\u10d8\u10db\u10e1\u10d8\u10d5\u10dc\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10db\u10d0\u10ea \u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10e1 \u10e8\u10d4\u10ea\u10d5\u10da\u10d8\u10da\u10d8 \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10de\u10d0\u10e0\u10d0\u10db\u10d4\u10e2\u10e0\u10d4\u10d1\u10d8 \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10e1\u10d8\u10db\u10e1\u10d8\u10d5\u10dc\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 (Kempuraj et al., 2004a). TNF-\u03b1-\u10d8\u10e1 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10e3\u10da\u10db\u10d0 \u10d3\u10dd\u10dc\u10d4\u10d4\u10d1\u10db\u10d0, \u10db\u10ec\u10d5\u10d0\u10d5\u10d4 \u10d0\u10dc \u10e5\u10e0\u10dd\u10dc\u10d8\u10d9\u10e3\u10da\u10d8 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd, \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0 \u10db\u10dd\u10db\u10d0\u10e2\u10d4\u10d1\u10e3\u10da\u10d8 \u10d9\u10dd\u10d2\u10dc\u10d8\u10e2\u10d8\u10e3\u10e0\u10d8 \u10d3\u10d0\u10e5\u10d5\u10d4\u10d8\u10d7\u10d4\u10d1\u10d0 AD-\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 (Holmes et al., 2009) \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0 PD-\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 (Litteljohn et al., 2010). \u10ec\u10d8\u10dc\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db TNF-\u03b1-\u10d8\u10e1 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d8\u10dc\u10d4\u10e5\u10ea\u10d8\u10d4\u10d1\u10d8 \u10d6\u10e0\u10d3\u10d0\u10e1\u10e0\u10e3\u10da \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10db\u10d8\u10d9\u10e0\u10dd\u10d2\u10da\u10d8\u10d0\u10e1, \u10e0\u10d0\u10d7\u10d0 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0\u10e1 \u10de\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10ee\u10d3\u10d4\u10dc\u10d4\u10dc \u10d3\u10dd\u10e4\u10d0\u10db\u10d8\u10dc\u10d4\u10e0\u10d2\u10e3\u10da\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d8\u10d9\u10d5\u10d3\u10d8\u10da\u10d8\u10e1 \u10d8\u10dc\u10d3\u10e3\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1 \u10e8\u10d0\u10d5 \u10dc\u10d8\u10d5\u10d7\u10d8\u10d4\u10e0\u10d4\u10d1\u10d0\u10e8\u10d8 (Qin et al., 2007), \u10d3\u10d0 \u10d4\u10e1 \u10d0\u10ee\u10d3\u10d4\u10dc\u10e1 \u10de\u10d8\u10e0\u10d3\u10d0\u10de\u10d8\u10e0\u10d8 \u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d8\u10e1 \u10d3\u10d4\u10db\u10dd\u10dc\u10e1\u10e2\u10e0\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1 \u10e1\u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10e1\u10d0 \u10d3\u10d0 \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1. \u10db\u10d4\u10e2\u10d8\u10ea, \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 \u10e8\u10d4\u10dc\u10d0\u10e0\u10e9\u10e3\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8, \u10e0\u10d0\u10db\u10d3\u10d4\u10dc\u10d8\u10db\u10d4 \u10db\u10e3\u10da\u10e2\u10d8\u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10e3\u10e0\u10d8 \u10de\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8, \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8 \u10d3\u10d0 T \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8 \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10d8\u10d3\u10d0\u10dc \u10db\u10d8\u10d2\u10e0\u10d8\u10e0\u10d4\u10d1\u10d4\u10dc \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8, \u10d3\u10d0 \u10db\u10d8\u10d3\u10d8\u10d0\u10dc \u10de\u10d8\u10e0\u10d3\u10d0\u10de\u10d8\u10e0 \u10d0\u10dc \u10d2\u10da\u10d8\u10e3\u10e0\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d5\u10da\u10d8\u10d7, \u10db\u10d0\u10e8\u10d8\u10dc, \u10e0\u10dd\u10ea\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8 \u10d8\u10d6\u10e0\u10d3\u10d4\u10d1\u10d8\u10d0\u10dc \u10d3\u10d0 \u10d8\u10dc\u10d0\u10e0\u10e9\u10e3\u10dc\u10d4\u10d1\u10d4\u10dc \u10e5\u10e0\u10dd\u10dc\u10d8\u10d9\u10e3\u10da \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d8\u10ec\u10d5\u10d4\u10d5\u10d4\u10dc \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d0\u10e1 (Prinz and Priller, 2017). \u10d7\u10e3\u10db\u10ea\u10d0, \u10d9\u10dd\u10db\u10e3\u10dc\u10d8\u10d9\u10d0\u10ea\u10d8\u10d0 \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10e1, \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10e1\u10d0 \u10d3\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 \u10ef\u10d4\u10e0 \u10d9\u10d8\u10d3\u10d4\u10d5 \u10d0\u10e0\u10d0\u10d0 \u10d2\u10d0\u10d2\u10d4\u10d1\u10e3\u10da\u10d8. \u10d0\u10db\u10d2\u10d5\u10d0\u10e0\u10d0\u10d3, \u10d0\u10db\u10df\u10d0\u10db\u10d0\u10d3 \u10ef\u10d4\u10e0 \u10d9\u10d8\u10d3\u10d4\u10d5 \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10d8 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10d5\u10d0\u10e0\u10d8\u10d0\u10dc\u10e2\u10d4\u10d1\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1. \u10db\u10e0\u10d0\u10d5\u10d0\u10da\u10db\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10d2\u10d5\u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d0 \u10d0\u10ee\u10d3\u10d4\u10dc\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10ec\u10e7\u10d4\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10de\u10e0\u10dd\u10d2\u10e0\u10d4\u10e1\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1 \u10ea\u10dc\u10e1-\u10e8\u10d8. \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc \u10e0\u10dd\u10da\u10e1 \u10d7\u10d0\u10db\u10d0\u10e8\u10dd\u10d1\u10d4\u10da \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10e3\u10e0 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d0\u10e8\u10d8, \u10e1\u10ee\u10d5\u10d0\u10d3\u10d0\u10e1\u10ee\u10d5\u10d0 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7\u10d8, \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10e5\u10e2\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0 \u10d5\u10d0\u10d6\u10dd\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d8 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e8\u10d5\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d6\u10d8\u10d7. \u10e0\u10d0\u10db\u10d3\u10d4\u10dc\u10d8\u10db\u10d4 \u10ec\u10d8\u10dc\u10d0 \u10db\u10d8\u10db\u10dd\u10ee\u10d8\u10da\u10d5\u10d8\u10d7\u10db\u10d0 \u10e1\u10e2\u10d0\u10e2\u10d8\u10d0\u10db \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10d2\u10dd\u10e0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10dd\u10e4\u10d0 \u10d0\u10dc\u10e2\u10d4\u10d1\u10d8\u10d7\u10d8 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d4\u10d1\u10d8\u10ea\u10d0\u10d0 IL-1, TNF-\u03b1, IL-6, \u10e5\u10d8\u10db\u10d8\u10d9\u10d8\u10dc\u10d8 (C-C \u10db\u10dd\u10e2\u10d8\u10d5\u10d8) \u10da\u10d8\u10d2\u10d0\u10dc\u10d3\u10d0 2 (CCL2), ROS \u10db\u10d8\u10d9\u10e0\u10dd\u10d2\u10da\u10d8\u10d0\u10e1, T-\u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10d4\u10e0, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10ee\u10d3\u10d4\u10dc\u10d4\u10dc \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d0\u10d7\u10d4\u10d1\u10d8\u10e1 \u10d8\u10dc\u10d3\u10e3\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1. \u10db\u10d8\u10e3\u10ee\u10d4\u10d3\u10d0\u10d5\u10d0\u10d3 \u10d8\u10db\u10d8\u10e1\u10d0, \u10e0\u10dd\u10db \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8 \u10d0\u10d7\u10d0\u10d5\u10d8\u10e1\u10e3\u10e4\u10da\u10d4\u10d1\u10d4\u10dc \u10dc\u10d4\u10d8\u10e0\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10e1, \u10d0\u10db \u10db\u10d8\u10db\u10dd\u10ee\u10d8\u10da\u10d5\u10d8\u10d7 \u10e1\u10e2\u10d0\u10e2\u10d8\u10d0\u10e8\u10d8 \u10e9\u10d5\u10d4\u10dc \u10d5\u10e4\u10dd\u10d9\u10e3\u10e1\u10d8\u10e0\u10d3\u10d4\u10d1\u10d8\u10d7 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10e8\u10d4\u10e0\u10e9\u10d4\u10e3\u10da \u10d0\u10e2\u10d8\u10de\u10e3\u10e0 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10e8\u10d8. \u10d4\u10e1 \u10db\u10d8\u10db\u10dd\u10ee\u10d8\u10da\u10d5\u10d0 \u10e4\u10dd\u10d9\u10e3\u10e1\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d6\u10d4, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d0\u10e1\u10dd\u10ea\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10dc\u10d8 \u10d0\u10e0\u10d8\u10d0\u10dc \u10de\u10d4\u10e0\u10d8\u10e4\u10d4\u10e0\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0 \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10d8\u10e1 \u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10d7 \u10db\u10d4\u10d3\u10d8\u10d0\u10e2\u10dd\u10e0\u10d4\u10d1\u10d6\u10d4 \u10d3\u10d0 \u10db\u10d0\u10e1\u10e2\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d6\u10d4 \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10db\u10d8\u10d2\u10e0\u10d8\u10e0\u10d4\u10d1\u10d4\u10dc \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 \u10de\u10d8\u10e0\u10d3\u10d0\u10de\u10d8\u10e0 \u10d0\u10dc \u10d0\u10e1\u10e2\u10e0\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8\u10e1, \u10db\u10d8\u10d9\u10e0\u10dd\u10d2\u10da\u10d8\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8\u10e1 \u10db\u10d4\u10e8\u10d5\u10d4\u10dd\u10d1\u10d8\u10d7, \u10d0\u10ee\u10d3\u10d4\u10dc\u10d4\u10dc \u10e0\u10d0 \u10dc\u10d4\u10d8\u10e1\u10dd\u10d0\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10d8\u10dc\u10d3\u10e3\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10e8\u10d4\u10dc\u10d0\u10e0\u10e9\u10e3\u10dc\u10d4\u10d1\u10d0\u10e1, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d8\u10ec\u10d5\u10d4\u10d5\u10d4\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d8\u10d9\u10d5\u10d3\u10d8\u10da\u10e1.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u10d8\u10d2\u10dc\u10da\u10d8\u10e1\u10e3\u10e0\u10d8 \u10d5\u10d4\u10e0\u10e1\u10d8\u10d8\u10e1 \u10d2\u10d0\u10d3\u10db\u10dd\u10ec\u10d4\u10e0\u10d0<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/therapia.ge\/wp-content\/uploads\/2023\/03\/brain-and-peripheral-atypical-inflammatory-mediators_.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"\u10e9\u10d0\u10d3\u10d2\u10db\u10d0 brain-and-peripheral-atypical-inflammatory-mediators_.\"><\/object><a id=\"wp-block-file--media-7c62755e-8cf3-4975-9085-13cb9ab2045f\" href=\"https:\/\/therapia.ge\/wp-content\/uploads\/2023\/03\/brain-and-peripheral-atypical-inflammatory-mediators_.pdf\">brain-and-peripheral-atypical-inflammatory-mediators_<\/a><a href=\"https:\/\/therapia.ge\/wp-content\/uploads\/2023\/03\/brain-and-peripheral-atypical-inflammatory-mediators_.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-7c62755e-8cf3-4975-9085-13cb9ab2045f\">\u10d2\u10d0\u10d3\u10db\u10dd\u10ec\u10d4\u10e0\u10d0<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u10d3\u10e3\u10e0\u10d0\u10d8\u10e1\u10d0\u10db\u10d8\u10d0 \u10d9\u10d4\u10db\u10de\u10e3\u10e0\u10d0\u10ef\u10d8, \u10f0\u10d0\u10e0\u10d8 \u10e1. \u10e2\u10e0\u10e3\u10db\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10ee\u10d4\u10da\u10dd\u10d1\u10d8\u10e1 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d0\u10d5\u10d0\u10d3\u10db\u10e7\u10dd\u10e4\u10dd, \u10d0\u10e8\u10e8-\u10d8\u10e1 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d7\u10d0 \u10e1\u10d0\u10e5\u10db\u10d4\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8, \u10d9\u10dd\u10da\u10e3\u10db\u10d1\u10d8\u10d0, MO, \u10e8\u10d4\u10d4\u10e0\u10d7\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10e2\u10d0\u10e2\u10d4\u10d1\u10d8 \u10e0\u10d0\u10db\u10d0\u10e1\u10d0\u10db\u10d8 \u10e2\u10d0\u10dc\u10d2\u10d0\u10d5\u10d4\u10da\u10d8, \u10db\u10d8\u10e1\u10e3\u10e0\u10d8\u10e1 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8\u10e1 \u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1&nbsp; \u10d3\u10d0 \u10e2\u10e0\u10d0\u10dc\u10e1\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d8,&nbsp; \u10d9\u10dd\u10da\u10e3\u10db\u10d1\u10d8\u10d0, MO, \u10e8\u10d4\u10d4\u10e0\u10d7\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10e2\u10d0\u10e2\u10d4\u10d1\u10d8 \u10d2\u10dd\u10d5\u10d8\u10dc\u10d3\u10d0\u10e1\u10d0\u10db\u10d8 \u10de.\u10e1\u10d4\u10da\u10d5\u10d0\u10d9\u10e3\u10db\u10d0\u10e0\u10d8, \u10f0\u10d0\u10e0\u10d8 \u10e1. \u10e2\u10e0\u10e3\u10db\u10d0\u10dc\u10d8\u10e1 \u10e1\u10d0\u10ee\u10d4\u10da\u10dd\u10d1\u10d8\u10e1 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d0\u10d5\u10d0\u10d3\u10db\u10e7\u10dd\u10e4\u10dd, \u10d0\u10e8\u10e8-\u10d8\u10e1 \u10d5\u10d4\u10e2\u10d4\u10e0\u10d0\u10dc\u10d7\u10d0 \u10e1\u10d0\u10e5\u10db\u10d4\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8, \u10d9\u10dd\u10da\u10e3\u10db\u10d1\u10d8\u10d0, MO, \u10e8\u10d4\u10d4\u10e0\u10d7\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10e2\u10d0\u10e2\u10d4\u10d1\u10d8 \u10e1\u10db\u10d8\u10e2\u10d0 \u10d6\u10d0\u10f0\u10d4\u10e0\u10d8, \u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10d3\u10d4\u10de\u10d0\u10e0\u10e2\u10d0\u10db\u10d4\u10dc\u10e2\u10d8 \u10d3\u10d0 \u10e2\u10e0\u10d0\u10dc\u10e1\u10da\u10d0\u10ea\u10d8\u10e3\u10e0\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d8, \u10db\u10d8\u10e1\u10e3\u10e0\u10d8\u10e1 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":99,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-97","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-utskhouri-gamotsdileba"],"_links":{"self":[{"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/posts\/97","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/comments?post=97"}],"version-history":[{"count":3,"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/posts\/97\/revisions"}],"predecessor-version":[{"id":110,"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/posts\/97\/revisions\/110"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/media\/99"}],"wp:attachment":[{"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/media?parent=97"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/categories?post=97"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/therapia.ge\/wp-json\/wp\/v2\/tags?post=97"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}